PLGD awareness week

What is Plasminogen Deficiency (PLGD)?

Plasminogen Deficiency (PLGD) is a rare condition that occurs when plasminogen (PLG) – a protein made in the liver – is reduced or almost absent.1 Patients with PLGD develop coarse, woody-like lesions on the thin layers (mucous membranes) of the skin and organs throughout the body. Some of the more common areas where these lesions can appear are eyes, ears, gums, respiratory tract and urinary tract.2 3 These lesions may cause pain or discomfort and can affect how a person’s organs work. Emergencies, such as a collapsed lung, kidney failure, and blindness may occur if these lesions are left untreated. In some cases, complications can be fatal.3

1. Tefs, K, Gueorguieva M, Klammt J, et al. Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patients. Blood. 200;108(9);30-21-3026.
2. Shoseyov D. Congenital plasminogen deficiency with respiratory complication. Powerpoint presentation at Hadassah Medical Center Jerusalem: Jerusalem, Israel.
3. Mehta R, Shapiro AD. Plasminogen activator inhibitor type I deficiency. Haemophilia. 2008;14(6);1255-1260.